Titanium Zirconium Molybdenum Ternary Alloy - Oral Planting Material

Titanium zirconium molybdenum ternary alloy (Y30) is an excellent performance oral planting material. The main ingredient is titanium (Ti), in order to improve overall performance on its basis doped with 5% zirconium (Zr) and 2% molybdenum (Mo). Zirconium is a neutral element, and its solid solution strengthening effect can improve the strength of Ti, molybdenum doped mainly to improve the tensile strength and corrosion resistance of titanium. In addition, doing polarity toxicity test, accumulation toxicity test, rat bone marrow cell chromosomal aberration test, pyrogen test, hemolysis test in vitro Chinese hamster ovary cell proliferation and other tests on titanium, zirconium, molybdenum found that the elements is security, non-toxic elements and has good biocompatibility as well. At the same time, doing the test of the physical properties, mechanical properties, and corrosion resistance found that titanium zirconium molybdenum ternary alloy is a safe and reliable oral planting material which has broad application prospects.

In order to evaluate the toxicity and safety of Y30 were done six biological safeties testing, and test reports are as follows:

1. Y30 leach liquor extract polar toxicity test: Using Y30 leach liquor injected the abdominal cavity of mice was observed after 14 days. The mice's diet, sleep, activity and growth are normal. The leach liquor is non-toxic to mice.

2. Y30 leach liquor accumulation (subacute) toxicity test, 25 days in a row using Y30 leach liquor injected mice, the cumulative amount reached 700cc / kg, the mice showed no death. It is shows that there is not cumulate effect on mice’s body.

3. Y30 leach liquor on rat bone marrow chromosome aberration test found the bone marrow cells of mice chromosome no effect chromosomal aberrations occur.

4. Y30 pyrogen test: injected rabbits with Y30 leach liquor after body temperature test found rabbit body temperature raise were below 0.6 ℃, in line with pyrogen test requirements.

5. Y30 hemolysis test: observe containing Y30 leach liquor of red blood cells found no fracture phenomena which described Y30 leach liquor afford hemolytic reaction.

6. Different concentrations of Y30 leach liquor in vitro hamster ovary (CHO) cell proliferation text: Y30 leach liquor does not affect the growth of CHO cells and it is kind of safe metal planting material.

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